| 货号 | 14029 |
| 描述 | Selective SIRT1 inhibitor (IC50 = 98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage (ref 1). Causes cell cycle arrest at G1 (ref 2). Inhibits differentiation and facilitates expansion of hematopoietic progenitor cells (ref 3). An extremely useful tool for determining the involvement of SIRT1 in cellular physiology (ref 4). Cell permeable. |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at 4°C for up to 2 years. Store solutions at -20°C for up to 2 months. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 248.7 |
| 分子式 | C13H13ClN2O |
| CAS号 | 49843-98-3 |
| 外观 | Light yellow powder. May be dissolved in DMSO (18 mg/ml); Ethanol (10 mg/ml). |
| 参考文献 | 1. JM Solomon et al. Mol. Cell Biol. 2006, 26:28 2. B Peck et al. Mol. Cancer Ther. 2010, 9:844 3. T Peled et al. Exp. Hematol.. 2012, 40:342 4. JL Andersen et al. Mol. Cell 2011, 43:834 |
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Chemical structure of EX-527. |
