Recombinant SUV420H1 (2-387) protein
货号：
81021 基本售价：
5727.5 元 规格：
50ug
产品信息
概述| 货号 | 81021 |
| 使用方法 | Recombinant SUV420H1 (2-387) is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
HMT Assay Conditions: 2 µg Recombinant Nucleosomes were incubated with different concentrations of SUV420H1 (2- 387) protein in 30 µl reaction system containing 50 mM Tris-HCl, pH 8.6, 0.02% Triton X-100, 2 mM MgCl2, 1 mM TCEP, and 50 µM SAM for 3 hours at room temperature. Western Blot was used to detect the generation of reaction products. |
性能| 供应商 | Active Motif |
| 背景 | SUV420H1 (Suppressor Of Variegation 4-20 Homolog 1, also known as KMT5B) is a histone methyltransferase that specifically trimethylates nucleosomal histone H4 on lysine 20 (H4K20). H4K20me3 is a histone marker that represents epigenetic transcriptional repression. SUV420H1 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins. It plays a role in myogenesis by regulating the expression of target genes, such as EID3. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant SUV420H1 (2-387) protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 5% glycerol. Please refer to product insert upon arrival for lot-specific concentration. |
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