CliniMACS CD62L MicroBeads
货号：
130-020-006 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-020-006 |
| 描述 | CD62L, also known as L-Selectin, LECAM-1, or LAM1, is a cell adhesion molecule on lymphocytes and belongs to the selectin family of proteins1. It recognizes sialylated carbohydrate groups and is continuously cleaved from the cell surface by ADAM17. CD62L acts as a homing receptor for lymphocytes to enter secondary lymphoid tissues via high endothelial venules and is commonly found on the cell surface of T cells. Naive T cells and central memory T cells express CD62L to localize in secondary lymphoid organs. CD62L is continuously endoproteolytically cleaved from the cell surface of CD62L-expressing neutrophils and lymphocytes (shedding). Proteolysis is accelerated, e.g., after antigen activation of T cells2.In clinical trials, a CD62L+ phenotype of T cells engineered with chimeric antigen receptors (CAR) has been reported to be associated with improved functionality3, extended persistence4 and superior clinical outcome5. The CliniMACS® CD62L Product Line consists of murine anti-CD62L monoclonal antibodies conjugated to superparamagnetic iron dextran particles. One vial contains 7.5 mL sterile, non-pyrogenic solution. The performance of the CliniMACS CD62L Product Line depends on the individual separation strategy. For information on respective capacities, refer to the package insert or contact your local representative.Please inquire about required CliniMACS System components and accessories. |
