MEK5 Pure 21/MEK5 150ug
货号：
610957 基本售价：
7771.0 元 规格：
150ug
产品信息
概述| 货号 | 610957 |
| 描述 | The mitogen-activated protein (MAP) kinase cascade participates in the Ras signal transduction pathway. The MAP kinase cascade consists of MEK kinase (Raf-1 or B-Raf), MAP/ERK kinase (MEK1 or MEK2), and extracellular-regulated protein kinase (ERK1 or ERK2). Raf becomes activated following its interaction with Ras-GTP (activated Ras). Via phosphorylation reactions, Raf activates MEK which, in turn, activates ERK. MEK5, also known as MAP Kinase 5, is a 50 kDa protein that is 40% identical to MEK1 and MEK2. Alternative splicing results in two MEK5 isoforms: α (50 kDa) and β (40 kDa). MEK5β has been reported to be ubiquitously expressed while MEK5α is expressed primarily in the liver and brain. The N-terminal amino acid sequence of MEK5α resembles sequences found in actin cytoskeletal proteins, indicating that MEK5α may associate with the cytoskeleton. However, the role ofMEK5 in the MAP kinase pathway and its substrate remain to be identified. |
| 别名 | MAP Kinase-5 |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human MEK5 aa. 13-188 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
