MEK2 Pure 96/MEK2 150ug
货号：
610236 基本售价：
7771.0 元 规格：
150ug
产品信息
概述| 货号 | 610236 |
| 描述 | MEK (Map/ErkKinase) 1 and 2 are serine/threonine kinases, also known as MAP kinase kinases (MAP2K1 and 2, MAPKK1 and 2, or MKK1 and 2). They activate the MAP (Mitogen-ActivatedProtein) kinases, also known as ERKs (Extracellular signal RegulatedKinases), which are critical kinases in multiple signal transduction pathways that regulate cell growth and differentiation. Activation of MEK 1 and 2 is dependent upon phosphorylation of serines 218 and/or 222 by activated MAP kinase kinase kinases (MAP3Ks), such as the Raf isoforms. Hormones, growth and differentiating factors, or tumor promoters induce Raf activation via activation of Ras proteins. MEK2 is seven amino acids larger and shares 81% identity with MEK1. In cultured cells, MEK2 is activated by serum. In vitro, v-Raf phosphorylates and activatesMEK2. It is thought that all of these activated protein kinases are downstream of the Ras signal transduction pathway and represent an integral part of the Ras mitogenic signal. The 96/MEK2 monoclonal antibody recognizes MEK2, regardless of phosphorylation status. |
| 别名 | MAP Kinase Kinase 2; ERK Kinase |
| 同种亚型 | IgG2a |
| 反应种属 | Mouse (QC Testing) Human, Rat, Dog, Chicken, Frog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat MEK2 aa. 1-110 Recombinant Protein |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
