NSF Pure 7/NSF 50ug
货号：
612272 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 612272 |
| 描述 | Eukaryotic protein trafficking involves the packaging of target molecules into membraneous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their components into an acceptor compartment. Components of both the vesicle and the plasma membrane interact to form a fusion complex, which mediates specific docking and fusion of vesicles. This complex contains NSF (N-ethyl-maleimide-sensitive factor), SNAPs (soluble NSF attachment proteins), and receptor proteins (SNAREs). SNAP-25 (synaptosome-associated protein of 25kDa) and syntaxin are SNAREs that are associated with the target plasma membrane (t-SNAREs), while synaptobrevin and synaptotagmin are vesicle-associated SNARE proteins (v-SNAREs). SNAREs form a 7S complex that has a high affinity binding site for α-SNAP and NSF. Upon binding of α-SNAP and NSF, a 20S complex is formed that is rapidly disassembled due to NSFs ATPase activity. This facilitates vesicle fusion to the target membrane followed by fusion and release of vesicle components. |
| 同种亚型 | IgG2b |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human NSF aa. 488-601 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
