Neurexin I Pure 17/Neurexin I 50ug
货号：
611882 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 611882 |
| 描述 | Neurexins are a family of neuron-specific cell surface proteins that contain hundreds of isoforms. These isoforms are generated from two different promoters in three different genes that code for many splice-variant transcripts. In rat, neurexins include 160-200 kDa α-neurexins and 90-100 kDa β-neurexins, which include multipe isoforms identified as neurexin I, II, or III. Full-length α-neurexins contain three repeating domains that include a left arm (A) cell interaction module (LNS), a central EGF domain, and a right arm (B) LNS. β-neurexins are identical to α-neurexins in the C-terminal region, but lack the five LNS repeats and three EGF domains of α -neurexins. Neurexin Iα was first characterized as a Ca2+-dependent receptor for α-latrotoxin, the excitatory neurotoxin in black widow spider venom. The C-terminus of Neurexin Iα interacts with the synaptic vesicle protein, synaptotagmin, while the three repeated sequences in the extracellular region have homology to cell adhesion-related proteins. Thus, Neurexin Iα may be important for cell-cell interactions and synaptic protein localization during the neuronal differentiation. |
| 同种亚型 | IgG1 |
| 反应种属 | Mouse (QC Testing) Human, Rat, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat Neurexin Iα aa. 1063-1184 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
