NCS-1 Pure 1/NCS-1 50ug
货号：
611578 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 611578 |
| 描述 | Ca2+-signaling pathways are critical for a variety of cell processes, such as gene expression, cytoskeletal dynamics, cell cycle, cell death, synaptic transmission, and basic cellular metabolism. A variety of EF-hand containing Ca2+-binding protein families have been implicated in neuronal Ca2+-regulated events. For instance, the neuronal Ca2+ sensor family (recoverin, neurocalcin, hippocalcin, VILIP, and neuronalCa 2+ sensor-1 (NCS-1) have been implicated in phototransduction signaling in photoreceptor cells and in exocytosis in presynaptic terminals. NCS-1 is the mammalian homologue of the Drosophila Ca2+-binding protein, frequenin. It contains four EF-hand motifs and an N-terminal myristolation site and is expressed in neurons, chromaffin cells, and glial cells. Overexpression of NCS-1 in chromaffin and PC12 cells increases Ca 2+-regulated exocytosis of dense-core granules. In vitro, NCS-1 activates a variety of enzymes, including calcineurin, cyclic nucleotide phosphodiesterase, and nitric-oxide synthase. Thus, NCS-1 is a Ca2+-binding protein that regulates a variety of cell signaling pathways involved with neuronal exocytosis. |
| 别名 | Neuronal Ca2+ Sensor-1 |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Human, Mouse (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat NCS-1 aa. 1-190 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
