STRAP Pure 22/STRAP 50ug
货号：
611346 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 611346 |
| 描述 | The transforming growth factor β(TGF-β) family of cytokines plays diverse and important roles in growth, development, and differentiation. Three high affinity TGF-β receptor types have been characterized. Both type I and type II receptors are type I transmembrane proteins which contain a Ser/Thr-kinase in their cytosolic domains. Type III receptor, also known as betaglycan, has no cytosolic signaling motif and functions in the presentation of TGF-β to the type I and type II receptors. The cytosolic domain kinase of the type I receptor is thought to be transphosphorylated by the corresponding kinase of the type II receptor, leading to activation of downstream substrates. Ser/Thrreceptorassociatedprotein (STRAP) contains six WD domains, which are characteristic of signal transduction proteins. STRAP can associate with both TGF-βI and TGF-βII receptors and overexpression of STRAP leads to inhibition of TGF-β-dependent transcriptional activation. STRAP is expressed ubiquitously in species ranging from yeast to human. Thus, STRAP may be an important element of TGF-β signal transduction pathways in a variety of tissues and species. |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Human (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse STRAP aa. 42-154 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
