IKK Gma Pure 54/IKKGma/NEMO 50ug
货号：
611306 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 611306 |
| 描述 | In most cells, NF- κ B is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins I κBα , I κBβ , and I κBε . Cell stimulation induces the release, activation, and nuclear translocation of NF- κ B. Release of NF- κ B results from the phosphorylation and subsequent proteolytic degradation of the I κ B proteins. Two cytokine-inducible I κ B kinases (IKK α and IKK β ) phosphorylate and target the I κ B proteins for degradation by the ubiquitin pathway. These kinases are components of a 700-900 kDa multisubunit complex that also contains NF- κ B/RelA, I κBα , MEKK1, NIK, IKAP, and IKK γ /NEMO (NF- κ B essential modulator). IKK γ contains two coiled-coil domains and a leucine zipper which allow it to form dimers and trimers that interact directly with IKK β . IKK γ , essential for IKK α/IKKβ activation of NF- κ B, is located functionally and physically upstream of these subunits. In addition, IKK γ enables the HTLV-1 Tax oncoprotein to interact with IKK β , resulting in constitutive activation of NF- κ B and maintenance of cellular transformation. Thus, IKK γ is an essential element of the I κ B complex and an adaptor that mediates stable formation of Tax-IKK complexes. |
| 别名 | NEMO |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Human, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse IKKγ/NEMO aa. 278-396 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
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| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
