TRF2 Pure 36/TRF2 50ug
货号：
611200 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 611200 |
| 描述 | Telomeres, the physical ends of eukaryotic chromosomes, consist of tracts of TTAGGG repeats that end in 3 single strand protrusions called G-strand overhangs. TRF2 (TTAGGG Repeat binding Factor-2) and TRF1 are two proteins that bind the TTAGGG repeats of mammalian telomeres. Both proteins are ubiquitously expressed and exhibit a similar overall structure with a C-terminal DNA binding motif related to the protooncogene Myb and an N-terminal putative dimerization domain. While TRF1 is a negative regulator of telomere length maintenance, TRF2 is involved in the protection of chromosome ends from end-to-end fusion. Telomere integrity is maintained through the formation of "t loops" which are made by the insertion of the G-strand overhang into the duplex repeat region. This structural alteration is mediated by TRF2 and is the primary mechanism for the sequestration and protection of telomeres from DNA damage responses. Cells that lack functional TRF2 undergo loss of G-strand overhangs, innapropriate DNA repair resulting in end-to-end chromosome fusion, cell cycle arrest and apoptosis. Thus, TRF2 is a unique and vital component for the maintenance of chromosome structure and function. |
| 别名 | TTAGGG Repeat binding Factor-2 |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human TRF2 aa. 316-427 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
