TFII-I Pure 42/TFII-I 50ug
货号：
610942 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 610942 |
| 描述 | General transcription factor II-I (GTF2I/TFII-I/SPIN/BAP-135) is a transcription factor that contains six directly repeated 90-residue regions, which possess helix-loop-helix protein-protein interaction motifs. TFII-I can regulate transcription in T-cells through interaction with the initiator elments (Inrs) within the AdML and V β promoters, and associates with HIV-1, TdT, and ribonucleotide reductase R1 Inrs. In addition, TFII-I associates with the E box motif, the CACGTG sequence, and with serum response element sequences. The helix-loop-helix repeats facilitate TFII-I interaction with other transcription factors, such as USF, Myc, Phox 1, MADS box protein serum response factor, and STATs. TFII-I was also identified as Brutons tyrosine kinase (btk)-associated protein (BAP-135). TFII-I/BAP-135 is tyrosine phosphorylated by btk and after EGF stimulation, and this phosphorylation enhances TFII-I transcriptional activity. The wide expression of TFII-I and the interaction of TFII-I with various Inrs and transcription factors implicates TFII-I in various signaling pathways that regulate gene transcription. |
| 别名 | BAP-135 |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human BAP-135 aa. 17-123 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
