HNF-1Alp Pure 2/HNF-1 50ug
货号：
610902 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 610902 |
| 描述 | HNF-1 (HepatocyteNuclearFactor1), a POU-homeodomain containing transcription factor, is a family member of liver-enriched transcription factors that also includes C-EBP, HNF-3, and HNF-4. Although HNF-1 exhibits elevated expression in liver and is thought to be involved in liver organogenesis, it is also found in kidney, stomach, intestine, and at a low level in thymus and spleen. A short N-terminal α-helical segment allows for HNF-1 homodimerization which is followed by DNA binding via an atypical helix-turn-helix motif. The HNF-1 dimer transactivates hepatic genes such as α- and β-fibrinogen,α-fetoprotein, albumin, α-L-antitrypsin, and pyruvate kinase by binding to a highly conserved 13 bp inverted palindromic sequence, GTTAATNATTAAC. HNF-1 represses its own transcription and data suggests that there is coordinate regulation between HNF-1 and HNF-4. Although HNF-4 induces HNF-1 transcription, HNF-1 downregulates HNF-4 activity by binding to the AF2 region in the activation domain of HNF-4. The ability of HNF-1 to dictate the production or activity of itself and other transcription factors indicates its possible function as a general cellular control mechanism. |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Human, Mouse (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse HNF-1 aa. 70-269 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
