p62 Lck Ligand Pure 3 50ug
货号：
610832 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 610832 |
| 描述 | p62 lck ligand (zeta-interacting protein (ZIP)) is a cytoplasmic protein that binds to the SH2 domain of lck (a T cell src tyrosine kinase) in the absence of a phosphotyrosine in either protein. The ubiquitously expressed p62 lck ligand contains a cysteine rich region that is similar to a zinc finger domain, a G protein binding region, a PEST sequence, and several phosphorylation sites. Deletion of the p62 lck ligand N-terminal domain has been reported to abrogate its binding to lck. However, mutation of the tyrosine did not have an effect. In addition, p62 lck ligand binds to the pseudosubstrate region of the PKC ζ catalytic domain. In turn, PKC ζ phosphorylates p62. p62 lck ligand binds to the dimerization region of PKC ζ , thereby inhibiting PKC ζ-PKCζ interaction. This suggests that p62 lck ligand may compete with PKC ζ . However, it requires PKC ζ for proper subcellular localization. These data suggest that p62 lck ligand may be part of the protein bridge that links PKC ζ to the tyrosine kinases involved in signaling pathways. |
| 别名 | Zeta Interacting Protein (ZIP); SQSMT1 |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human p62 lck ligand aa. 257-437 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
