FKBP12 Pure 8/FKBP12 50ug
货号：
610808 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 610808 |
| 描述 | Transforming growth factor-β binds to the TGFβ family of heteromeric serine/threonine transmembrane receptors (type I and type II). Following binding of TGFβ, the type II receptor (TβR-II) phosphorylates the type I receptor (TβR-I) which, in turn, conveys the signal. Since TβR-I and TβR-II can interact without the stimulation of TGFβ, leading to unwanted activation, a regulatory mechanism exists. In a yeast genetic screen, immunophilin FKBP12 was associated with the type I receptor. Studies including co-immunoprecipiation, deletion, and point mutations confirmed this interaction. FKBP12 inhibits TβR-II mediated phosphorylation of TβR-I, inhibiting activation. FKBP12 binds via its rapamycin/Leu-Pro binding pocket to the Leu-Pro sequence adjacent to the phosphorylation site of TβR-I. This interaction is blocked by the addition ofmacrolides, rapamycin, and FK506. Furthermore, mutations in the binding sites of FKBP12 and TβR-I abrogates the binding and results in activation of the receptor without the addition of TGFβ. Thus, FKBP12 is a regulatory protein for TβR-I and TβR-II-mediated signaling. |
| 别名 | FK506 Binding Protein 1A |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Dog, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human FKBP12 aa. 1-108 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
