RON Alp Pure 29/RON Alp 50ug
货号：
610744 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 610744 |
| 描述 | RON (Recepteur dOrigine Nantaise) is a tyrosine kinase receptor for MSP(Macrophage Stimulating Protein) that belongs to the hepatocyte growth factor receptor family. RON is synthesized as a single chain glycosylated polypeptide of 1400 amino acids that is cleaved upon maturation into a 150 kDa β-subunit with the kinase activity and a 40 kDa α-chain. Both chains are linked by disulfide bonds and the proper arrangement of the αandβ heterodimer is necessary for biological activity of RON. MSP induces the tyrosine kinase activity of RON, triggering a cascade of intracellular signaling that leads to DNA synthesis. However, RON activation in mouse erythroleukemia cells results in apoptosis. The replacement of autophosphorylation sites Y1330 and Y1337 abolishes both the mitogenic and apoptotic effects of MSP. Therefore, autophosphorylation at Y1330 and Y1337 is required for RONs biological activity. PLCγ, Shc, Grb2, p61, and p65 associate with RON. Although widely expressed, RON is particularly abundant in epithelial tissues, lung, brain, adrenal glands, gastrointestinal tract, kidney, and testis. |
| 别名 | Recepteur dOrigine Nantaise |
| 同种亚型 | IgG2b |
| 反应种属 | Dog (QC Testing) Human, Mouse, Rat, Frog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human RONα aa. 40-224 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
