FKBP51 Pure 18/FKBP51 50ug
货号：
610582 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 610582 |
| 描述 | FK506, one of several potent compounds that block T cell proliferation, is used in immunosuppressive therapy. Several FK506-binding proteins (FKBPs) have been identified in the search for intracellular targets of FK506. These proteins include FKBP12, FKBP12.6, and FKBP52. The immunosuppressive effects of FK506and FKBPs result from the inhibition of the calcineurin phosphatase, a well known component of the signaling cascade leading to IL-2 production. Calcineurin and FKBPs are widely distributed, therefore, it is difficult to achieve immunosuppressive specificity by FK506. FKBP51 (51kDa) is an FK506-binding protein that is expressed exclusively in T cells and has homology to FKBP52. Because of its limited distribution, FKBP51 may provide a more selective target for FK506 in T cells. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse FKBP51 aa. 4-199 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
