SRC-1 Pure 8/SRC-1 50ug
货号：
612378 基本售价：
3690.0 元 规格：
50ug
产品信息
概述| 货号 | 612378 |
| 描述 | Signal transduction via nuclear hormone receptors is important for cell growth and differentiation, development, and homeostasis. Nuclear hormone receptors are ligand-activated transcription factors that modulate target gene expression.These ligand/receptor complexes also interact with transcriptional coactivators which enhance ligand-dependent transcription. Various classes of coactivators have been identified, including SRC-1 and its related proteins, such as TIF-2/GRIP-1, RIP140, AIB-1, and TIF-1 α and -1ß. SRC-1 is a member of the basic helix-loop-helix-PAS domain family. It contains an N-terminal basic-helix-loop-helix (bHLH), two N-terminal PAS domains, and a glutamine-rich region near the C-terminus. SRC-1 interacts with many different steroid receptors and recruitment of SRC-1 to promoter sites may facilitate opening of chromatin structure via its histone acetyltransferase activity, as well as stabilization of the preinitiation complex. ERK-2 can phosphorylate SRC-1 at threonine and serine sites in vitro. In addition, SRC-1 expression in cells stimulated with EGF enhances progesterone receptor-mediated activation of a target reporter gene. Thus, SRC-1 is an important transcriptional co-activator involved in steroid receptor signaling. |
| 同种亚型 | IgG2a |
| 反应种属 | Human (QC Testing) Mouse, Rat (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human SRC-1 aa. 761-863 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
