Melusin Pure 42/Melusin 50ug
货号：
611894 基本售价：
3690.0 元 规格：
50ug
产品信息
概述| 货号 | 611894 |
| 描述 | Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are transmembrane heterodimers composed of αandβ subunits that are connected to the cytoskeleton. In mammals, at least 17 α subunits and 8 β subunits have been identified, and these proteins can heterodimerize to form at least 22 different receptors. The β1 subgroup of the integrin receptors consists of at least 6 different dimer combinations. A variety of signal transduction proteins have been shown to bind the cytoplamic domain of β1 integrins. These include melusin, ILK, ICAP, and RACK1. Melusin is expressed preferentially in muscle and heart, and contains putative SH3 domain binding motifs in the N-terminal region, two putative SH2 binding sites, and a C-terminal acidic amino acid stretch (CAAS) similar to the calcium binding proteins, calreticulin and calsequestrin. In muscle, melusin protein is localized in two rows flanking α-actinin at Z-lines, and melusin mRNA is upregulated during neonatal development. Differentiation of C2C12 murine myogenic cell line by serum starvation also upregulates melusin protein and mRNA. Thus, melusin may be an important signal transducer for β1 integrins during muscle development. |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Human, Mouse (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse Melusin aa. 61-258 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
