FEZ1 Pure 1/FEZ1 50ug
货号：
611710 基本售价：
3690.0 元 规格：
50ug
产品信息
概述| 货号 | 611710 |
| 描述 | The development of cancer is a multi-step process involving DNA alterations, oncogene activation, and/or the inactivation/deletion of an anti-onocogene or tumor suppressor. Tumor suppressors are involved in many facets of cell biology,such as cell cycle regulation and development. FEZ1 (F37/Esophageal cancer related gene-coding leucine zipper motif) is a putative DNA-binding protein with homology to cAMP-responsive activating-transcription factor 5 (Atf-5). The structure of FEZ1 includes DNA-binding and leucine zipper domains at amino acids 301-369 , as well as a putative cAMP-dependent phosphorylation site at Ser-29. FEZ1 is ubiquitously expressed in normal tissues with the most abundant expression in testes and brain, but is absent in 31 different cancer cell lines and 16 primary tumors. In addition, the FEZ1 gene has missense mutations in two primary esophageal cancers and a nonsense mutation in a prostate cancer cell line. Several FEZ1-expressing tumors have internally truncated FEZ1 mRNA transcripts. Thus, FEZ1 inactivation in cancers may involve both allelic loss and point mutations and implicates FEZ1 in cAMP-dependent tumor suppression. |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Human, Mouse (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human FEZ1 aa. 381-592 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
