MCM6 Pure 1/MCM6 50ug
货号：
611622 基本售价：
3690.0 元 规格：
50ug
产品信息
概述| 货号 | 611622 |
| 描述 | Mcm proteins are nuclear proteins that perform essential functions in the regulation of chromatin replication. They are primarily bound to chromatin during G1 and the beginning of S-phase, but are found in the nucleosol in postreplicative cells. Release of the bound Mcm proteins may be a mechanism for prevention of chromatin re-replication during S-phase. MCM6 is homologous to the yeast replication protein Mis5 and contains a DEFD-box motif and nucleotide-binding domain in the central region that are conserved in Mcm proteins. MCM6 forms a complex with MCM2, -4, and -7, which binds histone H3. In addition, the subcomplex of MCM4, -6, and -7 has helicase activity, which is mediated by the ATP-binding activity of MCM6 and the DNA-binding activity of MCM4. In Xenopus , formation of pre-replication complexes that include Mcm protein complexes requires phosphorylation, since intermediate phosphorylation of MCM4 correlates with Mcm protein complex formation and chromatin binding. Thus, Mcm proteins form heterocomplexes that participate in many different functions required for chromatin replication, such as DNA binding, helicase activity, and chromatin structure rearrangement. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF, Bioimg |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human MCM6 aa. 670-792 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
