JBP1/Skb1Hs Pure 32/JBP1 50ug
货号：
611538 基本售价：
3690.0 元 规格：
50ug
产品信息
概述| 货号 | 611538 |
| 描述 | p21[Cdc42/Rac]-activated kinases (PAKs) bind and are activated by the small GTPases, Cdc42 and Rac. In yeast, the interaction of the PAK, Shk1, with Skb1 (Shk1kinase binding protein 1) is important in the regulation of cell morphology and mitosis. Skb1Hs, the human homolog of Skb1, restores growth rates in yeast cells deficient for Skb1. Skb1Hs has also been identified as a 72 kDa pICln-binding protein (IBP72). pICln is thought to be a cytosolic regulator of a swelling-induced chloride channel and interactions with Skb1Hs suggest a link with PAKs, which are involved in cytoskeletal rearrangement. An additional line of study has identified Skb1Hs as a Jak binding protein (JBP1) via its interactions with Jak1-3 and Tyk2. This study also identified Skb1Hs as a methyltransferase that interacts with multiple proteins which possibly serve as physiological targets. Skb1Hs is expressed in a wide range of tissues and is thought to form homodimeric or multimeric complexes. Thus, Skb1Hs (IBP72, JBP1) is a multifunctional protein that may participate in such diverse processes as transcriptional and translational regulation, cytoskeletal rearrangement, and any of a number of signaling pathways. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Skb1Hs aa. 423-624 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
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| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
