mEPHX Pure 17/mEPHX 50ug
货号：
611372 基本售价：
3690.0 元 规格：
50ug
产品信息
概述| 货号 | 611372 |
| 描述 | Microsomal epoxide hydrolase (mEPHX/mEH/EPHX) is a bifunctional membrane protein that plays a role in the metabolism of reactive epoxide intermediates and in hepatocyte uptake of bile acids. mEPHX protein and nucleic acid sequence is evolutionarily conserved in human, rats, and rabbits and mEPHX protein expression is found in the embryo and multiple organs. Cellular expression of mEPHX has been localized to both the ER and sinusoidal plasma membrane. In the ER, mEPHX is expressed in two topological orientations. The type I orientated (Ccyt/Nexo) mEPHX remains in the ER, while the type II orientated (Cexo/Ncyto) mEPHX is localized to the plasma membrane. mEPHX metabolizes DMBA to both inert metabolites and metabolites that are electrophilic and possibly carcinogenic. mEPHX null-mice have been shown to be highly resistant to DMBA-induced carcinogenesis using skin cancer bioassays. Thus, mEPHX may have protective effects, such as bile acid uptake and reactive epoxide metabolism, as well as harmful effects related to the production of carcinogens. |
| 别名 | Microsomal Epoxide Hydrolase; mEH; EPHX |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Chicken, Frog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human mEPHX aa. 13-125 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
