FBP Pure 6/FBP 50ug
货号：
611286 基本售价：
3690.0 元 规格：
50ug
产品信息
概述| 货号 | 611286 |
| 描述 | Thec-myc proto-oncogene is an essential participant in regulation of normal cell proliferation and programmed cell death. The far-upstream FUSE Binding Protein (FBP) is one of many factors that bind to a single strand of DNA in the 5 region of the c-mycgene. FBP, FBP2, and FBP3 comprise a family of single-strand DNA binding proteins that possess many features found in more conventional transcription factors. All FBP proteins bind specifically to a single strand of FUSE via a centrally located DNA binding domain and all contain a potent C-terminal transactivation domain. The transactivation domain of FBP contains three motif copies composed of tyrosine diads. However, a single tyrosine motif is sufficient to activate transcription. The N-terminal portion of FBP can repress the C-terminal transactivation potential. This repression is thought to be mediated by interactions between N- and C-terminal domains that produce an inactive conformation. Although FBP2 and FBP3 exhibit no specific pattern of expression, FBP expression mimics that of c-myc. These data implicate FBP as a transcription factor that is important for the regulation of cell growth and differentiation. |
| 别名 | FUSE Binding Protein |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human FBP aa. 61-180 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
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| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
