DFF45 Pure 19/DFF45 50ug
货号：
611036 基本售价：
3690.0 元 规格：
50ug
产品信息
概述| 货号 | 611036 |
| 描述 | Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic cells are characterized by loss of cell volume, plasma membrane blebbing, nuclear condensation, chromatin aggregation, and endonucleocytic degradation of DNA into nucleosomal fragments. Caspase-3 (CPP32, Yama, apopain) is the most extensively studied apoptotic protein. An apoptotic signal induces the intracellular cleavage of caspase-3 from an inactive proform to an active fragment. The active form of caspase-3 cleaves several other apoptotic proteins including DNA Fragmentation Factor (DFF). DFF is thought to be either directly or indirectly responsible for the DNA laddering that is a hallmark of apoptosis. It is a heterodimer of 40 kDa (DFF40) and 45 kDa (DFF45) subunits. Cleavage of DFF45 into three fragments is a prerequisite for DFF-mediated DNAfragmentation. Identity of the DFF fragment that mediates DNA laddering remains unclear. However, it is clear that DFF functions downstream of caspase-3 and is essential for the characteristic fragmentation of DNA during apoptosis. |
| 别名 | DNA Fragmentation Factor-45 |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human DFF45 aa. 105-305 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
