PKC-Alp (pT497) PE K14-984 50Tst
货号：
560141 基本售价：
3675.0 元 规格：
50Tst
产品信息
概述| 货号 | 560141 |
| 描述 | The Protein Kinase C (PKC) family of serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. Three categories exist, conventional PKC (cPKC), novel PKC (nPKC), and atypical PKC (aPKC). All have C-terminal kinase domains, which are closely related to those of protein kinases A and B (Akt), and variable N-terminal regulatory domains that give them different modes of activation. For example, cPKC ( a,bI,b II, and g isoforms) are calcium-activated, phospholipid-dependent serine/threonine-specific enzymes that can also be activated by phorbol esters. However, nPKC ( d,e,h , and q isoforms) and aPKC ( z,i , and l isoforms) are Ca2+-independent. aPKC are unique in that their activity is independent of diacylglycerols and phorbol esters. Phosphorylation at three conserved sites in the kinase domain is required for catalytic activity. Specifically, the threonine 497 (T497) of PKC a is in the activation loop of the kinase domain and is phosphorylated by the constitutively active phosphoinositide-dependent kinase-1 (PDK-1). The K14-984 monoclonal antibody recognizes the phosphorylated T497 in the kinase domain of human PKC a. |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) Mouse (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | IC/FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human PKCα Peptide |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
