PLC-Gma2 Alexa 488 K86-1161 50Tst
货号：
560135 基本售价：
3675.0 元 规格：
50Tst
产品信息
概述| 货号 | 560135 |
| 描述 | The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLC- g is the only member that contains SH2 and SH3 domains. These domains enable it to interact with receptor tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: 1) PLC- g 1, which is ubiquitously expressed, and 2) PLC g 2, found primarily in the lymphoid system. PLC- g is essential for growth factor-induced cell motility and mitogenesis. Overexpression of PLC- g is evident in several forms of cancer, and it has been identified as a key mediator of PDGF-dependent cellular transformation. Thus regulation of PLC- g activity by growth factors is involved in cell growth and transformation. Although the immunogen for generation of the K86-1161 monoclonal antibody was a phosphorylated peptide, peptide blocking studies demonstrated that the mAb recognizes PLC- g 2 regardless of phosphorylation status. This antibody was raised to a unique region of PLC- γ 2 and is predicted not to crossreact with PLC- γ1 |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) Mouse (Reactivity Confirmed in Development) |
| 来源宿主 | Mouse |
| 使用方法 | IC/FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human PLC-γ2 Peptide |
| 标记 | Alexa Fluor 488 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 488 under optimum conditions, and unreacted Alexa Fluor® 488 was removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
