HNF-1 Bta Pure 25/HNF-1Bta 50ug
货号：
612504 基本售价：
3564.0 元 规格：
50ug
产品信息
概述| 货号 | 612504 |
| 描述 | HNFs (Hepatocyte Nuclear Factor) are POU-homeodomain-containing liver enriched transcription factors that include HNF1- α , HNF1- β , HNF-3 α , HNF-3 β , HNF-4 and HNF-6. HNF-1 is expressed in liver, kidney, and intestine, while HNF-1 β is expressed highest in kidney with lower levels in intestine, lung, and liver. Both HNF-1 and HNF-1 β have short N-terminal α -helical segments that facilitate homodimerization (A-domain), a region related to POU-specific A-box (B-domain), and a homeodomain (C-domain). The HNF-1 and HNF-1 β homo- and hetero-dimers transactivate genes required for development of various tissues. Both transcription factors can bind the consensus HNF1 inverted palindromic sequence GTTAATNATTAAC. HNF-1 represses its own transcription and data suggests that there is coordinate regulation between HNF-1 and HNF-4. Although HNF-4 induces HNF-1 transcription, HNF-1 downregulates HNF-4 activity by binding to the AF2 region in the activation domain of HNF-4. Thus, HNF transcription factors may be involved in various aspects of the regulation of gene transcription throughout development. |
| 别名 | Hepatocyte Nuclear Factor-1β |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Human, Mouse, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse HNF-1β aa. 1-101 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
