Ronin/THAP11 PE P56-507 50Tst
货号：
562549 基本售价：
3525.0 元 规格：
50Tst
产品信息
概述| 货号 | 562549 |
| 描述 | Thanatos-associated proteins (THAPs) are characterized by the THAP domain, which is a conserved Drosophila P element transposase DNA-binding domain. THAPs are DNA-binding factors involved in cell proliferation, apoptosis, cell cycle and transcriptional regulation. THAP11 is an essential factor in embryogenesis and ES cell pluripotency and binds directly to host cell factor 1 (HCF-1), a key regulator of transcriptional control. THAP11 has been designated as Ronin, named for a masterless Japanese samurai because of its lack of any apparent relationship to Nanog, Oct4 and Sox2the master regulators of pluripotency. Ronin/THAP11 binds to the c-Myc promoter and down-regulates c-Myc expression. Recently, it was reported that Bcr-Abl inhibited the expression of THAP11 in Chronic myelogenous leukemia (CML) cells and promoted CML cell proliferation by the aberrant induction of c-Myc expression. |
| 别名 | Ronin, THAP11 |
| 同种亚型 | Mouse IgG2b, κ |
| 反应种属 | Human (QC Testing) Mouse (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Ronin/THAP11 Recombinant Protein |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
