概述| 货号 | RDC1103 |
| 别名 | CD340 antigen; CD340; c-erb B2/neu protein; EC 2.7.10; HER2; HER-2; HER2EC 2.7.10.1; herstatin; Metastatic lymph node gene 19 protein; MLN 19; MLN19; Neu Oncogene; NEUHER-2/neu; neuroblastoma/glioblastoma derived oncogene homolog; NGL; NGLTKR1; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian) |
全称 | Receptor Tyrosine Protein Kinase ErbB2 | | 反应种属 | Mouse |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 2064 (Human); 13866 (Mouse); 24337 (Rat) |
| 背景 | ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Cancer Biomarkers
- Cancer Stem Cell Markers
- EGF Family
- Human CD Marker Products
- ICC / IHC Images: ErbB2/Her2
- Mini-review: The ERK Signal Transduction Pathway
- Receptor Tyrosine Kinases (RTKs)
- Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
- Receptors in the Jak/STAT Pathway
- Semaphorins, Plexin Receptors, and Related Molecules
- The ErbB Family - Talk and Crosstalk
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