Human ALK/CD246 (NP 004295) VersaClone cDNA (10 UG)
货号：
RDC1376 基本售价：
11332.3 元 规格：
10 ug
产品信息
概述| 货号 | RDC1376 |
| 别名 | ALK tyrosine kinase receptor; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246 antigen; CD246; EC 2.7.10.1; Ki-1; NBLST3; Tcrz |
全称 | Anaplastic Lymphoma Kinase | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 238 (Human); 11682 (Mouse); 266802 (Rat) |
| 背景 | Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Human CD Marker Products
- Receptor Tyrosine Kinases (RTKs)
- Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
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