| 货号 | RDC1059 |
| 别名 | patched (Drosophila) homolog 2; patched 2; patched homolog 2 (Drosophila); patched homolog 2; protein patched homolog 2; ptc2; PTCH2 |
| 反应种属 | Human |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 8643 (Human); 19207 (Mouse) |
| 背景 | Patched 2 (Ptch2) is a 180 - 200 kDa 12 transmembrane member of the Patched family. Human PTCH2 is 1203 amino acids (aa) in length. It has two terminal cytoplasmic domains, one between aa 1 - 57, and a second between aa 1115 - 1203. Together with Smoothened (SMO), Ptch2 forms a membrane complex that serves as a receptor for Sonic Hedgehog (SHH). Human Ptch2 likely has two isoforms. One shows an eight aa extension of the C-terminus, while a second shows a four aa substitution for the C-terminal 61 amino acids (aa 1143 - 1203). Over the first extracellular loop human Patched 2 shares 95% and 96% aa sequence identity with mouse and canine Patched 2, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
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