Human Insulin R/CD220 (NP 000199) VersaClone cDNA (10 UG)
货号：
RDC1239 基本售价：
11332.3 元 规格：
10 ug
产品信息
概述| 货号 | RDC1239 |
| 别名 | CD 220; CD220 antigen; CD220; EC 2.7.10; EC 2.7.10.1; HHF5; INSR; insulin receptor; IR |
全称 | Insulin Receptor | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3643 (Human); 16337 (Mouse) |
| 背景 | Insulin Receptor (INSR, CD220) is a type I transmembrane glycoprotein in the Insulin/IGF Receptor family of receptor tyrosine kinases. The mature receptor contains an extracellular alpha subunit and an extracellular/transmembrane/cytoplasmic beta subunit. Alternative splicing generates A and B isoforms which may homodimerize or heterodimerize with the IGF-I receptor. All receptor combinations bind Insulin, IGF-I, or IGF-II, but with differing affinities. Insulin R signaling regulates glucose uptake and metabolism but also contributes to cell growth, differentiation and apoptosis. Mutations in INSR have been linked to severe insulin resistance (type A and Rabson-Mendenhall syndrome), type II diabetes mellitus, and leprechaunism (Donohue syndrome). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Cytokines in Lipid/Cholesterol Metabolism
- Diabetes
- Glucose Homeostasis
- Growth Hormone/IGF-I Axis
- Human CD Marker Products
- Nutrition and Appetite
- Protein/Peptide Hormones and Regulators
- Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
- Receptors in the Jak/STAT Pathway
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