概述| 货号 | RDC0983 |
| 别名 | glutamate receptor, metabotropic 1; GPRC1A; GRM1; GRM1A; metabotropic glutamate receptor 1; mGluR1; MGLUR1A; MGLUR1GPRC1AmGlu1 |
全称 | Metabotropic Glutamate Receptor 1 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 2911 (Human); 14816 (Mouse); 24414 (Rat) |
| 背景 | Metabotropic glutamate receptor 1 (mGluR1) is a 130 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. On neurons, mGluR1 is postsynaptic, associates with Gq-like proteins, mobilizes intracellular Ca++, and influences ion channel activity. Mature mGluR1 is 1176 amino acids (aa) in length and contains a 574 aa N-terminal extracellular domain (ECD) (aa 19-592). The ECD binds glutamate and forms either a covalent homodimer or heterodimer with CaSR. There is one alternative splice form for human mGluR1 that shows a 20 aa substitution for the C-terminal 308 amino acids. Over aa 33-522, human mGluR1 shares more that 98% aa identity with mouse, rat and canine mGluR1. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Glutamate Receptors
- ICC / IHC Images: mGluR1
- Neurotransmitter G Protein-Coupled Receptors
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