货号 | RDC2054 |
别名 | DAG kinase iota; DGKI; DGKiota; DGK-iota; diacylglycerol kinase iota; diacylglycerol kinase, iota; Diglyceride kinase iota; EC 2.7.1.107 | 全称 | Diacylglycerol Kinase, iota 64kDa |
供应商 | R&D Systems |
Entrez Gene IDs | 9162 (Human); 320127 (Mouse); 688705 (Rat) |
背景 | DGK (Diacylglycerol kinase alpha) proteins are type I members of the eukaryocytic diacylglycerol kinase family of enzymes, possessing EF-hand, C1/Cys-rich zinc finger and catalytic domains. DGK-alpha in IL-2-stimulated T cells translocates to the nucleus, promoting proliferation. TCR stimulation, however, promotes anergy. DGK-alpha also participates in VEGF or HGF-mediated motility in endothelial, epithelial, or cancer cells. DGK-gamma is highly enriched in the retina and cerebellar Purkinje cells, and presence of unactivated protein in the nucleus may regulate the cell cycle. |
运输条件 | Blue Ice |
存放说明 | -20℃ |
参考文献 |
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