概述| 货号 | RDC1707 |
| 别名 | Agammaglobulinaemia tyrosine kinase; AGMX1; AGMX1MGC126262; AT; ATKIMD1; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; EC 2.7.10; EC 2.7.10.2; IMD1; PSCTK1; tyrosine-protein kinase BTK; XLA; XLAMGC126261 |
全称 | Bruton Agammaglobulinemia Tyrosine Kinase |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 695 (Human) |
| 背景 | Bruton tyrosine kinase (Btk) is a 75 kDa cytoplasmic protein tyrosine kinase that is widely expressed in hematopoietic cells. Btk is required for B cell receptor signaling and B cell development. Defects in Btk result in X-linked agammaglobulinemia which is characterized by a severely decreased level of circulating antibodies. Like other Tec family kinases, Btk contains a Pleckstrin homology domain, a Tec homology domain, an SH3 domain, an SH2 domain, and a protein kinase domain. Association of the Btk SH2 domain with the B cell linker protein (BLNK) is required for the activation of PLC? by Btk. The autophosphorylation of Tyr223 facilitates the interaction of Btk with activated Syk. Within the SH2 domain (aa 280 - 377), human Btk shares 99% aa sequence identity with mouse and rat Btk. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - B Cell Activation
- C-type Lectin Receptors
- ICC / IHC Images: BTK
- Intracellular Kinases in the Akt Pathway
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