概述| 货号 | RDC0886 |
| 别名 | CHNG1; LGR3; LGR3hTSHR-I; MGC75129; seven transmembrane helix receptor; thyroid stimulating hormone receptor; Thyroid-stimulating hormone receptor; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH-R |
全称 | Thyroid Stimulating Hormone Receptor | | 反应种属 | Mouse |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 7253 (Human); 22095 (Mouse) |
| 背景 | TSH R (Thyroid Stimulating Hormone Receptor) confers responsiveness to the endocrine hormones Thyrotropin/TSH and Thyrostimulin. TSH is produced by the anterior pituitary and triggers the thyroid gland to release thyroxine (T4). T4 is then converted to triiodothyronine (T3) which exerts wide-ranging effects on growth and metabolism. The heterodimeric TSH R is primarily expressed by epithelial cells of the thyroid (thyrocytes). TSH R is the dominant target of autoreactive agonistic antibodies in Graves’ disease but is a more rare target in Hashimoto’s thyroiditis. The activation of TSH R in brown adipose tissue can trigger the upregulation of UCP-1 as well as thermogenesis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Protein/Peptide Hormones and Regulators
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