概述| 货号 | RDC1169 |
| 别名 | IL-12 receptor beta 2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL12RB2; IL-12RB2; IL-12R-beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain; interleukin-12 receptor subunit beta-2 |
全称 | Interleukin 12 Receptor beta 2 | | 反应种属 | Mouse |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3595 (Human); 16162 (Mouse) |
| 背景 | The biological activities of IL-12 are mediated through a receptor complex composed of two class I cytokine receptor subunits designated IL-12 R beta 1 and IL-12 R beta 2. Both subunits are required for high-affinity binding and activity of IL-12. IL-12 R beta 1 binds specifically to IL-12 p40, a subunit of the heterodimeric IL-12, and is also a subunit of the IL-23 receptor complex, while IL-12 R beta 2 binds IL-12 p35. IL-12 Rs are predominantly expressed on NK cells and activated T (Th1) cells with some expression also on dendritic cells. Both IL-12 R subunit extracellular domains are composed of three fibronectin-like domains and two cytokine receptor homology domains. IL-12R beta 2 also has an extracellular Ig-like domain. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - B Cell Markers
- Cytokines and Receptors in Allergy and Asthma
- Cytokines and Receptors in Angiogenesis
- Group 1 ILCs
- IL-12 Family
- Isolation, Culture, and Identification of Natural Killer Cells
- Receptors in the Jak/STAT Pathway
- T Cell Cytokine Signaling
- Th1 Cells
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