概述| 货号 | RDC1454 |
| 别名 | Acute-phase response factor; APRFMGC16063; DNA-binding protein APRF; FLJ20882; HIES; signal transducer and activator of transcription 3 (acute-phase responsefactor); signal transducer and activator of transcription 3 |
全称 | Signal Transducer and Activator of Transcription 3 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 6774 (Human); 20848 (Mouse); 25125 (Rat) |
| 背景 | The STAT family of transcription factors, first described as key mediators of interferon signal transduction, are now recognized as signaling factors downstream of many cytokines, growth factors, and hormones. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. They are characterized structurally by the presence of the Src homology 2 (SH2) domain, and a C-terminal tyrosine phosphorylation site. Upon ligand binding, they are recruited to the activated receptor, via their SH2 domains, to receptor-associated tyrosine kinases of the Janus kinase family (JAK). Once phosphorylated by JAK, STATS are free to hetero- or homo-dimerize, and translocate to the nucleus where they bind DNA to regulate gene transcription. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Apoptosis Transcription Factors and Regulators
- B Cell Markers
- Cancer Stem Cell Transcription Factors
- Chemokine Receptor Intracellular Signaling
- Common gamma Chain Receptor Family
- Dendritic Cell Development
- Embryonic and Induced Pluripotent Stem Cell Markers
- Epithelial Stem Cell Transcription Factors
- Focal Adhesions
- Gametes and Fertilization
- GDNF Family
- Hematopoietic Stem Cell Transcription Factors and Regulators
- ICC / IHC Images: STAT3
- IL-10/Interferon Family
- IL-12 Family
- Immunoglobulin-Like Domain Transcription Factors
- Interactive Pathway: Th17 Differentiation
- Intracellular Signaling Molecules in Angiogenesis
- Jak and STAT Proteins
- Mesenchymal Stem Cell Transcription Factors
- Mini-review: STAT Proteins
- Myeloid-derived Suppressor Cells (MDSC)
- Neural Stem Cell Transcription Factors
- PDGF Family
- Pluripotent Stem Cell Transcription Factors
- Signaling Molecules and Transcriptional Regulators of Tfh Cell Differentiation
- STAT
- Th17 Cells
- Th22 Cells
- Transcription Factors in the Akt Pathway
- Transcriptional Regulators in Allergy and Asthma
- VEGF Family
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