概述| 货号 | RDC1452 |
| 别名 | MGF; signal transducer and activator of transcription 5A; STAT5 |
全称 | Signal Transducer and Activator of Transcription 5 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 6776 (Human); 20850 (Mouse) |
| 背景 | Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6, IFN-α). STAT5 has two isoforms (A and B) that share 93% amino acid identity and bind the DNA consensus site TTCN3GAA. STAT5 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Apoptosis Transcription Factors and Regulators
- Cancer Stem Cell Transcription Factors
- Common gamma Chain Receptor Family
- Hematopoietic Stem Cell Markers
- Hematopoietic Stem Cell Transcription Factors and Regulators
- IL-10/Interferon Family
- IL-12 Family
- Immunoglobulin-Like Domain Transcription Factors
- Jak and STAT Proteins
- Mini-review: STAT Proteins
- PDGF Family
- Regulatory T Cells (Tregs)
- STAT
- Th2 Cells
- Transcription Factors in the Akt Pathway
- Transcriptional Regulators in Allergy and Asthma
|
