概述| 货号 | RDC1552 |
| 别名 | B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22 molecule; CD22; sialic acid binding Ig-like lectin 2; Sialic acid-binding Ig-like lectin 2; SIGLEC-2; SIGLEC2FLJ22814; T-cell surface antigen Leu-14 |
全称 | Sialic Acid Binding Ig-like Lectin 2 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 933 (Human); 12483 (Mouse) |
| 背景 | Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Acute Lymphoblastic Leukemia
- B Cell Activation
- B Cell Markers
- Dendritic Cell Activation
- Dendritic Cell Adhesion and Migration
- Dendritic Cell ITIM/ITAM Immunoreceptors
- Human CD Marker Products
- ICC / IHC Images: Siglec-2/CD22
- Ig-type Lectins
- ITIM/ITAM Immunoreceptors and Related Molecules
- Lymphoid Lineage Markers
- Lymphoma
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