概述| 货号 | RDC1419 |
| 别名 | FH; FHC; LDL receptor; LDLCQ2; low density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3; low-density lipoprotein receptor |
全称 | Low Density Lipoprotein Receptor | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3949 (Human); 16835 (Mouse); 300438 (Rat) |
| 背景 | LDL R (Low Density Lipoprotein Receptor) is a widely expressed cell surface scavenger receptor. LDL R binds ApoB and ApoE, the apolipoproteins of low- and very low-density lipoproteins (LDL and VLDL), respectively. Hepatocyte LDL R is responsible for endocytosis and clearing of most plasma LDL cholesterol. At the low pH of the endocytic vesicle, it dissociates, allowing degradation of LDL and recycling of LDL R to the cell surface. Lack of LDL R expression or function causes familial hypercholesterolemia (FH). The protease PCSK9 can also cause increased plasma cholesterol by promoting LDL R degradation rather than recycling to the cell surface. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - APP Cleavage and Amyloid-beta Degradation
- ICC / IHC Images: LDL R
- Lipid/Cholesterol Metabolism
- Lipoprotein Receptors and Associated Proteins
- Obesity
- Scavenger Receptors
|
