概述| 货号 | RDC0396 |
| 别名 | beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b antigen; CD140b; EC 2.7.10; EC 2.7.10.1; JTK12; PDGFR; PDGFR1; PDGFRB; PDGF-R-beta; platelet-derived growth factor receptor, beta polypeptide |
全称 | Platelet-derived Growth Factor Receptor beta | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 5159 (Human); 18596 (Mouse); 24629 (Rat) |
| 背景 | PDGF isoforms exert their cellular effects by binding to the structurally similar receptor tyrosine kinases (RTK), PDGF R alpha (CD140a) and PDGF R beta (CD140b). PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of RTK which are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization leading to signal transduction. The expression of PDGF alpha and beta receptors is independently regulated in various cell types. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Cancer Biomarkers
- Human CD Marker Products
- ICC / IHC Images: PDGF R beta
- PDGF Family
- PDGF Family Receptors
- Platelets
- Receptor Tyrosine Kinases (RTKs)
- Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
- Receptors in the Jak/STAT Pathway
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