| 货号 | 39874 |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot/Immunofluorescence/Immunohistochemistry/Immunocytochemistry |
| 使用方法 | Validated Applications: WB: 1:500 - 1:1,000 dilution Published Applications: IHC ICC/IF See references for more information. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This macroH2A2 antibody was raised against a peptide corresponding to amino acids 162-372 of human macroH2A2. |
| 背景 | Histone macroH2A2 is a histone H2A variant and one of the three members of the macroH2A family. The three macroH2A proteins contain the C-terminal macro domain in addition to the H2A homologous region. This macro domain may bind poly ADP-ribose and other NAD+ metabolites. The macroH2A1.1 and macroH2A1.2 proteins are produced from alternatively spliced transcripts from the macroH2A1 gene while a second distinct macroH2A gene encodes macroH2A2. In mammals, macroH2A is preferentially localized to the inactive X chromosome and in general is proposed to play a role in repressing gene expression. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 40 kDa |
| 参考文献 |
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Histone macroH2A2 antibody (pAb) tested by Western blot. U2OS cells mock transfected (lane 1) or transfected with GST-tagged macroH2A1.1 (lane 2), GST-macroH2A1.2 (lane 3) or GST-macroH2A2 (lane 4) were probed with Histone macroH2A2 antibody at a dilution of 1:1,000. |
