MCF-7 nuclear extract (H2O2 treated)
货号：
40800 基本售价：
2465.0 元 规格：
200 ug
产品信息
概述| 货号 | 40800 |
| 使用方法 | MCF-7 nuclear extract (H2O2 treated) is recommended for studies related to 1) breast cancer research, 2) cellular response to oxidative stress and 3) apoptosis. |
性能| 供应商 | Active Motif |
| 背景 | MCF-7 nuclear extract (H2O2treated) was prepared from cell cultures of the human MCF-7 breast adenocarcinoma cancer cell line. The MCF-7 cell line was originally derived from a pleural effusion of a 69-year old Caucasian woman with metastatic breast cancer. MCF-7 cells are the best characterized and most commonly utilized cell lines in in vitro breast cancer studies. The MCF-7 cell line has retained several characteristics that are particular to mammary epithelium, including the ability to grow as a monolayer, form domes, and respond to hormones. These cells also display a low metastatic potential, leading to the assumption that they represent an early epithelial adenocarcinoma phenotype. These characteristics make MCF-7 cells an ideal model system to study malignant progression in relation to breast cancer.
Treatment of MCF-7 cells with reactive oxygen species (ROS), such as H2O2 triggers an oxidative stress response that leads to toxicity and eventual apoptosis. H2O2 signals an antiproliferative/repair response that induces antioxidant systems to metabolize H2O2 to avert ROS toxicity. |
| 运输条件 | Dry Ice |
| 存放说明 | To ensure stability, extracts should be stored at -80°C.
We recommend aliquoting the extracts into single-use fractions and then storing them at -80°C. This eliminates repeated freeze/thaw cycles. |
| 外观 | 2 x 100 µg of MCF-7 nuclear extract (H2O2 treated) at 2.5 µg/µl. |
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