MCF-7 nuclear extract (Estradiol treated)
货号：
36016 基本售价：
2465.0 元 规格：
200 ug
产品信息
概述| 货号 | 36016 |
| 使用方法 | MCF-7 nuclear extract (Estradiol treated) is specifically recommended for studies related to breast cancer research. |
性能| 供应商 | Active Motif |
| 背景 | MCF-7 nuclear extract (Estradiol treated) was prepared from cell cultures of the human MCF-7 breast adenocarcinoma cancer cell line. The MCF-7 cell line was originally derived from a pleural effusion of a 69-year old Caucasian woman with metastatic breast cancer. MCF-7 cells are the best characterized and most commonly utilized cell lines in in vitro breast cancer studies. The MCF-7 cell line has retained several characteristics that are particular to mammary epithelium, including the ability to grow as a monolayer, form domes, and respond to hormones. These cells also display a low metastatic potential, leading to the assumption that they represent an early epithelial adenocarcinoma phenotype. These characteristics make MCF-7 cells an ideal model system to study malignant progression in relation to breast cancer.
Like mammary epithelial cells, MCF-7 cells are sensitive to estrogen. These cells process estrogen, in the form of estradiol, via cytoplasmic estrogen receptors. Treatment of with estradiol induces a proliferative response by activating the expression of early and delayed hormone-responsive genes required for cell cycle progression. In addition, estradiol treatment of MCF-7 cells causes inhibition of apoptosis. |
| 运输条件 | Dry Ice |
| 存放说明 | To ensure stability, extracts should be stored at -80°C.
We recommend aliquoting the extracts into single-use fractions and then storing them at -80°C. This eliminates repeated freeze/thaw cycles. |
| 外观 | 200 µg of MCF-7 nuclear extract (Estradiol treated) at 6.69 µg/µl. |
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