A-431 nuclear extract (EGF treated)
货号：
36003 基本售价：
2465.0 元 规格：
200 ug
产品信息
概述| 货号 | 36003 |
| 使用方法 | A-431 nuclear extract (EGF treated) is specifically recommended for analysis of 1) EGFR expression and downstream signaling cascades, 2) cell cycle, and 3) cancer-associated signaling pathways. |
性能| 供应商 | Active Motif |
| 背景 | A-431 nuclear extract (EGF treated) was prepared from cell cultures of the human epidermoid carcinoma A431 cell line. These cells are characterized by abnormally high levels of expression of epidermal growth factor receptor (EGFR), approximately 3 x 106/cell, on the cell surface and exhibits a biphasic response to varying concentrations of epidermal growth factor (EGF). Specifically, lower (pmol) concentrations of EGF stimulates cell growth while higher (nmol) concentrations inhibits cell growth and induces terminal differentiation. Therefore, these cells are commonly used as a positive control for EGFR expression and in studies of EGFR downstream signaling cascades. These cells are also highly responsive to mitogenic stimuli and are naturally devoid of p53 and so are also frequently used in cancer and cell cycle-associated studies. |
| 运输条件 | Dry Ice |
| 存放说明 | To ensure stability, extracts should be stored at -80°C.
We recommend aliquoting the extracts into single-use fractions and then storing them at -80°C. This eliminates repeated freeze/thaw cycles. |
| 外观 | 200 µg of A-431 nuclear extract (EGF treated) at 2.5 µg/µl. |
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