Recombinant DNMT1 protein
货号：
31335 基本售价：
6162.5 元 规格：
10 ug
产品信息
概述| 货号 | 31335 |
| 别名 | AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN |
| 使用方法 | Recombinant DNMT1 is suitable for use in DNA methylation assays. This protein is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | DNMT1–DNA methyltransferase 1(orDNMT 1) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA, commonly at the C5 position of a CpG dinucleotide. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3 (comprised of DNMT3A and DNMT3B).
DNMT1 is the most abundant DNMT in somatic cells and shows a preference for methylating hemi-methylated DNA. It is considered to be a maintenance DNA methyltransferase that is important in the maintenance of specific patterns of methylation throughout cellular divisions. Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as embryonic development, genetic imprinting, X chromosome inactivation and the control of gene expression. DNA methylation is generally associated with transcriptional repression. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | 10 µg recombinant DNMT1 protein supplied at a concentration of 0.06 µg/µl in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2mM KCl, 0.04% Tween-20, 5.7 mM glutathione, and 20% glycerol. |
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