Recombinant PRDM5 protein
货号：
31494 基本售价：
5872.5 元 规格：
20 ug
产品信息
概述| 货号 | 31494 |
| 别名 | BCS2, PFM2 |
| 使用方法 | Recombinant PRDM5 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | PRDM5 (PR Domain Containing 5) is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Mutations of PRDM5 causes Type 2 brittle cornea syndrome (BCS2) which is an inherited connective tissue disease with a devastating ocular phenotype through histone and DNA methylation. PRDM5 is a relevant tumour suppressor gene that is frequently targeted in colorectal tumourigenesis. Promoter methylation-mediated downregulation of PRDM5 contributes to the development of lung squamous cell carcinoma. It is a sequence-specific DNA-binding transcription factor and represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Full length recombinant PRDM5 protein was expressed in Sf9 cells and is supplied in 25 mM Hepes pH 7.5, 400 mM NaCl, 5% Glycerol, 0.04% Triton X-100, 0.2 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration. |
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