Recombinant SETMAR protein
货号：
31454 基本售价：
5872.5 元 规格：
20 ug
产品信息
概述| 货号 | 31454 |
| 别名 | Mar1; HsMar1; METNASE |
| 使用方法 | Recombinant SETMAR is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | SETMAR (SET Domain and mariner transposase fusion gene) is a ubiquitously expressed nuclear fusion protein that contains an N-terminal SET domain with histone methyltransferase activity and a C-terminal mariner (MAR) transposase domain that recognizes and binds DNA. The gene exists as a fusion gene only in anthropoid primates; other organisms lack mariner transposase domain. SETMAR binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The mariner transposase domain recognizes and binds the 19-mer core of the 5’-TIR (terminal inverted repeats) of the Hsmar1 element. The SET domain specifically methylates lysines 4 and 36 of histone H3 which are epigenetic marks associated with transcriptional activation. SETMAR demonstrates in vivo end joining activity and may mediate genomic integration of foreign DNA. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Full length recombinant SETMAR protein expressed in Sf9 cells at a concentration of 1 mg/ml in 25 mM HEPES, pH 7.5, 150 mM NaCl and 5% glycerol. |
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参考图片Recombinant SETMAR protein gel.
SETMAR protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. |
